The game begins at 8 p.m. Saturday at the Home Depot Center in Carson.
The Spartans are 14-0 so far this season after dominating Folsom High, 49-15, last week to win the Northern California championship.
De La Salle is ranked by MaxPreps Sports as the second best high school team in California and the fifth best team in the nation.
The Huskies are 14-1. Their only loss was a 40-35 defeat in the first game of the season against St. Bonaventure of Ventura.
Centennial is ranked by MaxPreps Sports as the top team in California and the fourth best team in the nation.
They won the Southern California championship last week by knocking off Narbonne High of Harbor City, 41-34.